Evaluation of Anti-diabetic Activity of Aqueous and Methanolic Extracts of C. tinctorius L. (Safflower Florets)

Alloxan was one of the usual substances used for induction diabetes mellitus. It has a destructive effect on β cells pancreas. Glibenclamide an oral sulphonylurea antidiabetic preparation and widely as standard drug in study. In hypoglycaemic study C. tinctorius L. petals extract alloxan induced diabetic rats, significant increase serum fasting blood glucose level with decrease body weight were observed. On other hand, treatment to animals produced dose related effects. The increased brought down gain seen.
 effectively normal rats that are reflected by elevated levels glucose, glycosylated Hb reduced weight, liver, pancreas kidney glycogen, insulin injected animals. Treatment glibenclamide methanolic aqueous extracts reversed these conditions. While comparing plant study, showed better activity than extract. Decrease glycogen content control due leakage state. Prevention depletion liver following administration could have been achieved stimulation release. highest improvement recorded 600 mg/kg b.w. dosage (petals).